CAN MONTH OF BIRTH AND UV RADIATION AFFECT MULTIPLE SCLEROSIS RISK IN PROVINCES OF IRAN?
Abstract
Introduction: Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system that affects women more than men. Environmental factors such as sunlight, through Ultraviolet (UV) radiation can have a pivotal role in MS prevalence. MS is more common in mid latitude temperate climatic areas, such as the northern United States, southern Canada and northern Europe. It has been shown that there is a low risk of MS in the hot, moist and extremely dry equatorial zone, and vice versa.
Materials and methods: In this study, UV radiation data as UV index were collected from a geographic database provided by The Environmental Health Information System of Islamic Republic of Iran. The monthly average UV index during pregnancy leading to 15th of each month has been used to create GIS maps by using ArcGIS 9.3.
Results: In this paper, It was focused on the potential effect of UV radiation on MS prevalence. It was found that there is a low maternal exposure to UV radiation in people born in April and May in all provinces of Iran and they can be more susceptible to MS.
Conclusions: This study shows that Iranian high exposure to UV radiation can reduce the risk of MS. It was indicated that Iran is a low risk area for MS and people born in April and May are more susceptible to MS due to low exposure to UV radiation. Thus, birth months could be considered as an important factor in MS prevalence.
Greer JM, McCombe PA. Role of gender in multiple sclerosis: clinical effects and potential molecular mechanisms. Journal of neuroimmunology. 2011;234(1):7-18.
Lee S, Xu L, Shin Y, Gardner L, Hartzes A, Dohan FC, et al. A potential link between autoimmunity and neurodegeneration in immune-mediated neurological disease. Journal of neuroimmunology. 2011;235(1):56-69.
Smolders J, Damoiseaux J, Menheere P, Hupperts R. Vitamin D as an immune modulator in multiple sclerosis, a review. Journal of neuroimmunology. 2008;194(1):7-17.
Hanwell HE, Banwell B. Assessment of evidence for a protective role of vitamin D in multiple sclerosis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2011;1812(2):202-12.
de Abreu DAF, Landel V, Féron F. Seasonal, gestational and postnatal influences on multiple sclerosis: the beneficial role of a vitamin D supplementation during early life. Journal of the neurological sciences. 2011;311(1):64-8.
Ebers GC. Environmental factors and multiple sclerosis. The Lancet Neurology. 2008;7(3):268-77.
Chaudhuri A. Why we should offer routine vitamin D supplementation in pregnancy and childhood to prevent multiple sclerosis. Medical hypotheses. 2005;64(3):608-18.
Sellner J, Kraus J, Awad A, Milo R, Hemmer B, Stüve O. The increasing incidence and prevalence of female multiple sclerosis—a critical analysis of potential environmental factors. Autoimmunity reviews. 2011;10(8):495-502.
Mowry EM. Vitamin D: evidence for its role as a prognostic factor in multiple sclerosis. Journal of the neurological sciences. 2011;311(1):19-22.
Milo R, Kahana E. Multiple sclerosis: geoepidemiology, genetics and the environment. Autoimmunity reviews. 2010;9(5):A387-A94.
Norval M. The challenges of UV-induced immunomodulation for children’s health. Progress in biophysics and molecular biology. 2011;107(3):323-32.
Halliday GM, Damian DL, Rana S, Byrne SN. The suppressive effects of ultraviolet radiation on immunity in the skin and internal organs: implications for autoimmunity. Journal of dermatological science. 2012;66(3):176-82.
Robyn M, Anne P. Ultraviolet radiation and health: friend and foe. MJA. 2002;117(11/12):594-8.
Vermeer B, Hurks M. New trends in photobiology: The clinical relevance of immunosuppression by UV irradiation. Journal of Photochemistry and Photobiology B: Biology. 1994;24(3):149-54.
Ahn B-N, Kim J-A, Kong C-S, Seo Y, Kim S-K. Protective effect of (2′ S)-columbianetin from Corydalis heterocarpa on UVB-induced keratinocyte damage. Journal of Photochemistry and Photobiology B: Biology Biology. 2012;109:20-7.
Feister U, Laschewski G, Grewe R-D. UV index forecasts and measurements of health-effective radiation. Journal of Photochemistry and Photobiology B: Biology. 2011;102(1):55-68.
Tabari H, Talaee PH. Temporal variability of precipitation over Iran: 1966–2005. Journal of Hydrology. 2011;396(3):313-20.
Moghtaderi A, Rakhshanizadeh F, Shahraki-Ibrahimi S. Incidence and prevalence of multiple sclerosis in southeastern Iran. Clinical neurology and neurosurgery. 2013;115(3):304-8.
Kitron U, Bouseman JK, Jones CJ. Use of the ARC/ INFO GIS to study the distribution of Lyme disease ticks in an Illinois county. Preventive Veterinary Medicine. 1991;11(3):243-8.
Freedman DM, Dosemeci M, Alavanja MC. Mortality from multiple sclerosis and exposure to residential and occupational solar radiation: a case-control study based on death certificates. Occupational and Environmental Medicine. 2000;57(6):418-21.
Marrie RA. Environmental risk factors in multiple sclerosis aetiology. The Lancet Neurology. 2004;3(12):709-18.
Moghtaderi A, Rakhshanizadeh F, Shahraki-Ibrahimi S. Incidence and prevalence of multiple sclerosis in southeastern Iran. Clinical neurology and neurosurgery. 2013;115(3):304-8.
Saadatnia M, Etemadifar M, Maghzi AH. Multiple sclerosis in Isfahan, Iran. International review of neurobiology. 2007;79:357-75.
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| Issue | Vol 1 No 1 (2016): Winter 2016 | |
| Section | Articles | |
| Keywords | ||
| Multiple sclerosis UV radiation birth month. | ||
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