DETERMINATION OF URINARY CONCENTRATIONS OF ORGANIC SOLVENT IN URBAN WORKERS
Abstract
Introduction: Concerns about indoor air quality have drawn researcher’s attention in the last years. This becomes more important with knowledge of that 90% of people’s daily times are spent inside the home and workplaces. Solvents are an example of prevalent hazard chemical, which are less-studied comparing pesticides or metals. Chlorinated solvents such as carbon tetrachloride, chloroform, and dichloromethane constitute an important class of solvent, which applies for a variety of consumer and industrial cleaning purposes especially in the laboratory. Mentioned components represent various side effects and carcinogenic implication that could adversely affect workers exposed to solvents.
Materials and Methods: In the present study the excretion of urinary carbon tetrachloride, chloroform, and dichloromethane were evaluated as biomarkers of exposure to chlorinated solvents. With this aim, forty chemistry laboratory technicians from several universities in Tehran and forty occupationally non-exposed persons were investigated. Spot urine samples were obtained prior to and at the end of the work shift from each subject. The urinary levels of chlorinated solvents were determined by using headspace gas chromatography and mass spectrometry detection.
Results: The mean concentrations of chloroform and dichloromethane in chemistry laboratory technicians were significantly greater than the control groups. Although the mean levels of carbon tetrachloride before the work shift in technicians were higher than the occupationally non-exposed group, a statistically significant difference could not be observed (Pvalue= 0.324).
Conclusions: The results showed that the laboratory technicians are one of the most exposed groups among occupationally exposed people with the main route of exposure through inhalation.
Pekey H, Arslanbaş D. The relationship between indoor, outdoor and personal VOC concentrations in homes, offices and schools in the metropolitan region of Kocaeli, Turkey. Water, Air, and Soil Pollution. 2008;191(1-4):113-29.
Kamal A, Malik RN, Fatima N, Rashid A. Chemical exposure in occupational settings and related health risks: A neglected area of research in Pakistan. Environmental Toxicology and Pharmacology. 2012;34(1):46-58.
Pilidis GA, Karakitsios SP, Kassomenos PA, Kazos EA, Stalikas CD. Measurements of benzene and formaldehyde in a medium sized urban environment. Indoor/ outdoor health risk implications on special population groups. Environmental monitoring and assessment. 2009;150(1-4):285-94.
Loh MM, Levy JI, Spengler JD, Houseman EA, Bennett DH. Ranking cancer risks of organic hazardous air pollutants in the United States. Environmental Health Perspectives. 2007;115(8):1160.
Tang X, Eke PE, Scholz M, Huang S. Processes impacting on benzene removal in vertical-flow constructed wetlands. Bioresource technology. 2009;100(1):227-34.
Caudle WM, Guillot TS, Lazo CR, Miller GW. Industrial toxicants and Parkinson’s disease. Neurotoxicology. 2012;33(2):178-88.
Armstrong SR, Green LC. Chlorinated hydrocarbon solvents. Clinics in occupational and environmental medicine. 2004;4(3):481-96, vi.
Bale AS, Barone Jr S, Scott CS, Cooper GS. A review of potential neurotoxic mechanisms among three chlorinated organic solvents. Toxicology and applied pharmacology. 2011;255(1):113-26.
Perrin D, Armarego W. DR Perrin Purification of laboratory chemicals: Pergamon Press, Oxford; 1980.
Ruder AM. Potential health effects of occupational chlorinated solvent exposure. Annals of the New York Academy of Sciences. 2006;1076(1):207-27.
Green T, Dow J, Ong C, Ng V, Ong H, Zhuang Z, et al. Biological monitoring of kidney function among workers occupationally exposed to trichloroethylene. Occupational and environmental medicine. 2004;61(4):312-7.
Brüning T, Pesch B, Wiesenhütter B, Rabstein S, Lammert M, Baumüller A, et al. Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case‐control study in Arnsberg, Germany. American journal of industrial medicine.
;43(3):274-85.
Lock EA, Zhang J, Checkoway H. Solvents and Parkinson disease: A systematic review of toxicological and epidemiological evidence. Toxicology and applied pharmacology. 2013;266(3):345-55.
Cancer IAfRo. Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide: IARC; 1999.
Fustinoni S, Consonni D, Campo L, Buratti M, Colombi A, Pesatori AC, et al. Monitoring low benzene exposure: comparative evaluation of urinary biomarkers, influence of cigarette smoking, and genetic polymorphisms. Cancer Epidemiology Biomarkers & Prevention. 2005;14(9):2237-44.
Fustinoni S, Mercadante R, Campo L, Scibetta L, Valla C, Consonni D, et al. Comparison between urinary o-cresol and toluene as biomarkers of toluene exposure Journal of occupational and environmental hygiene. 2007;4(1):1-9.
Ghittori S, Ferrari M, Maestri L, Negri S, Zadra P, Gremita P, et al. Il significato del monitoraggio ambientale e biologico nei lavoratori addetti alle stazioni di servizio dopo la eliminazione del piombo tetraetile dalle benzine. G Ital Med Lav Erg. 2005;27(2):137-53.
Campo L, Fustinoni S, Buratti M, Cirla PE, Martinotti I, Foà V. Unmetabolized polycyclic aromatic hydrocarbons in urine as biomarkers of low exposure in asphalt workers. Journal of occupational and environmental hygiene. 2007;4(S1):100-10.
Sobus JR, McClean MD, Herrick RF, Waidyanatha S, Nylander-French LA, Kupper LL, et al. Comparing urinary biomarkers of airborne and dermal exposure to polycyclic aromatic compounds in asphaltexposed workers. Annals of occupational hygiene. 2009;53(6):561-71.
ACGIH CO. TLVs and BEIs Based on the Documentation of the Threshold Limit Values for Chemical Substances and Physical Agents, and Biological Exposure Indices. American Conference of Governmental Industrial Hygienists Cincinnati. 2008.
Scibetta L, Fustinoni S, Campo L, Valla C, Costamagna P, Consonni D, et al., editors. valutazione di MTBE urinario come indicatore biologico di esposizione a traffico autoveicolare. Congresso Nazionale della Società Italiana di Medicina del Lavoro ed Igiene Industriale. 2005;27(3):315.
Janasik B, Jakubowski M, Jałowiecki P. Excretion of unchanged volatile organic compounds (toluene, ethylbenzene, xylene and mesitylene) in urine as result of experimental human volunteer exposure. International archives of occupational and environmental health. 2008;81(4):443-9.
Ducos P, Berode M, Francin J, Arnoux C, Lefèvre C. Biological monitoring of exposure to solvents using the chemical itself in urine: application to toluene. International archives of occupational and environmental health. 2008;81(3):273-84.
Hrivňák J, Kráľovičová E. Simple Method for Analysis of Unmetabolized BTEX in Urine Samples. Petroleum & Coal. 2009;51(3):164-6.
Jia C, Yu X, Masiak W. Blood/air distribution of volatile organic compounds (VOCs) in a nationally representative
sample. Science of the Total Environment. 2012;419:225-32.
Fabrizi G, Fioretti M, Rocca LM. Occupational exposure to complex mixtures of volatile organic compounds in ambient air: desorption from activated charcoal using accelerated solvent extraction can replace carbon disulfide? Analytical and bioanalytical chemistry. 2013;405(2-3):961-76.
Lin Y, Egeghy P, Rappaport S. Relationships between levels of volatile organic compounds in air and blood from the general population. Journal of Exposure Science and Environmental Epidemiology. 2007;18(4):421-9.
D’Souza JC, Jia C, Mukherjee B, Batterman S. Ethnicity, housing and personal factors as determinants of VOC exposures. Atmospheric Environment. 2009;43(18):2884-92.
Rastkari N, Yunesian M, Ahmadkhaniha R, Jabbari H. Determination of Urinary Concentrations of Organic Oxygenates in Urban Workers. Iran J Environ Health Sci Eng. 2010;7(1):81-6.
Rastkari N, Ahmadkhaniha R, Yunesian M. Simultaneous determination of trichloroethylene, perchloroethylene and trichloroacetic acid in human urine using solid-phase microextraction fibre coated with singlewalled carbon nanotubes. International Journal of Environmental Analytical Chemistry. 2012;92(14):1650-65.
Sarkhosh M, Mahvi AH, Zare MR, Fakhri Y, Shamsolahi HR. Indoor contaminants from hardcopy devices: characteristics of VOCs in photocopy centers. Atmospheric Environment. 2012;63:307-12.
Alwis KU, Blount BC, Britt AS, Patel D, Ashley DL. Simultaneous analysis of 28 urinary VOC metabolites using ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS). Analytica chimica acta. 2012;750:152-60.
Imbriani M, Ghittori S. Gases and organic solvents in urine as biomarkers of occupational exposure: a review. International archives of occupational and environmental health. 2005;78(1):1-19.
Poli D, Manini P, Andreoli R, Franchini I, Mutti A. Determination of dichloromethane, trichloroethylene and perchloroethylene in urine samples by heads pace solid phase microextraction gas chromatography–mass spectrometry. Journal of Chromatography B.
;820(1):95-102.
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| Issue | Vol 1 No 1 (2016): Winter 2016 | |
| Section | Articles | |
| Keywords | ||
| Chloroform dichloromethane chlorinated solvents Biomarkers | ||
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