A review on effect of air pollutants on fetal development and pregnancy outcomes
,
Abstract
Developing fetus is connected to the mother by placenta to receive oxygen and nutrients. Maternal exposure to ambient air pollution not only affects maternal health but also provides a pathway for many toxic pollutants to cross the placental barrier and interrupt biochemical milieu. There are numerous scientific studies available describing possible negative health impact of air pollutants on reproductive health, pregnancy outcomes and fetal development yet no toxic effect is available recently. Studying the pollutants exposure effect on fetal development is crucial for the underlying mechanism between prenatal exposure and pregnancy outcomes. Present review meticulously provides the compiled data of 40 most recent studies with possible action mechanism of air pollutants on pregnancy outcomes and fetal development to find a better solution to exterminate or reduce the problem.
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4. Cao Z, Meng L, Zhao Y, Liu C, Yang Y, Su X, et al. Maternal exposure to ambient fine particulate matter and
fetal growth in Shanghai, China. Environmental health. 2019;18(1):49.
5. Alderete TL, Song AY, Bastain T, Habre R, Toledo‐Corral CM, Salam MT, et al. Prenatal traffic‐related air pollution exposures, cord blood adipokines and infant weight. Pediatric obesity. 2018;13(6):348-56.
6. Balakrishnan K, Sambandam S, Ramaswamy P, Ghosh S, Venkatesan V, Thangavel G, et al. Establishing integrated rural–urban cohorts to assess air pollutionrelated health effects in pregnant women, children and adults in Southern India: an overview of objectives, design and methods in the Tamil Nadu air pollution and health effects (TAPHE) study. BMJ open. 2015;5(6): e008090.
7. Balakrishnan K, Ghosh S, Thangavel G, Sambandam S, Mukhopadhyay K, Puttaswamy N, et al. Exposures
to fine particulate matter (PM2.5) and birthweight in a rural-urban, mother-child cohort in Tamil Nadu, India. Environmental research. 2018;161:524-31.
8. Basu R, Pearson D, Ebisu K, Malig B. Association between PM2.5 and PM2.5 constituents and preterm delivery in California, 2000–2006. Paediatric and perinatal epidemiology. 2017;31(5):424-34.
9. Brauer M, Lencar C, Tamburic L, Koehoorn M, Demers P, Karr C. A cohort study of traffic-related air pollution
impacts on birth outcomes. Environmental health perspectives. 2008;116(5):680-6.
10. Bunkar N, Bhargava A, Chaudhury K, Sharma RS, Lohiya NK, Mishra PK. Fetal nucleic acids in maternal
plasma: from biology to clinical translation. Frontiers in Bioscience. 2018; 23:397-431.
11. Choe SA, Jun YB, Lee WS, Yoon TK, Kim SY. Association between ambient air pollution and pregnancy rate
in women who underwent IVF. Human reproduction. 2018;33(6):1071-8.
12. Conde PG, Farhat L LC, Braga AL, Sallum AE, Farhat SC, Silva CA. Are prematurity and environmental factors
determinants for developing childhood-onset systemic
lupus erythematosus? Modern rheumatology. 2018;28(1):156-60.
13. Contreras ZA, Heck JE, Lee PC, Cui X, Hobel CJ, Janzen C, et al. Prenatal air pollution exposure, smoking, and uterine vascular resistance. Environmental epidemiology (Philadelphia, Pa.). 2018;2(3).
14. Dodd-Butera T, Quintana PJ, Ramirez-Zetina M, Batista- Castro AC, Sierra MM, Shaputnic C, et al. Placental biomarkers of PAH exposure and glutathione-S-transferase biotransformation enzymes in an obstetric population from Tijuana, Baja California, Mexico. Environmental research. 2017;152:360-8.
15. Ebisu K, Malig B, Hasheminassab S, Sioutas C, Basu R. Cause-specific stillbirth and exposure to chemical constituents and sources of fine particulate matter. Environmental research. 2018;160: 358-64.
16. Gehring U, Tamburic L, Sbihi H, Davies HW, Brauer M. Impact of noise and air pollution on pregnancy outcomes.
Epidemiology. 2014;25(3):351-8.
17. Stieb DM, Chen L, Eshoul M, Judek S. Ambient air pollution, birth weight and preterm birth: a systematic
review and meta-analysis. Environmental research. 2012;117:100-11.
18. Golan R, Kloog I, Almog R, Gesser-Edelsburg A, Negev M, Jolles M, et al. Environmental exposures and
fetal growth: The Haifa pregnancy cohort study. BMC public health. 2018;18(1):132.
19. Guo LQ, Zhang Q, Zhao DD, Wang LL, Chen Y, Mi BB, et al. Relationship between air pollution exposure during
pregnancy and birth weight of term singleton livebirth newborns. Zhonghua liu xing bing xue za zhi= Zhonghua liuxingbingxue zazhi. 2017;38(10):1399- 403.
20. Guo T, Wang Y, Zhang H, Zhang Y, Zhao J, Wang Q, et al. The association between ambient PM2.5 exposure
and the risk of preterm birth in China: A retrospective cohort study. Science of the total environment. 2018;633:1453-9.
21. Ha S, Sundaram R, Louis GM, Nobles C, Seeni I, Sherman S, et al. Ambient air pollution and the risk of pregnancy loss: a prospective cohort study. Fertility and sterility. 2018;109(1):148-53.
22. Johnson S, Bobb JF, Ito K, Savitz DA, Elston B, Shmool JL, et al. Ambient fine particulate matter, nitrogen dioxide,
and preterm birth in New York city. Environmental health perspectives. 2016;124(8):1283-90.
23. Kingsley SL, Eliot MN, Glazer K, Awad YA, Schwartz JD, Savitz DA, et al. Maternal ambient air pollution, preterm
birth and markers of fetal growth in Rhode Island: results of a hospital-based linkage study. Journal of epidemiology
and community health. 2017;71(12):1131-6.
24. La Marca L, Gava G. Air Pollution Effects in Pregnancy. In: Clinical handbook of air pollution-related diseases 2018:479-494 Springer, Cham.
25. Lakshmi PV, Virdi NK, Sharma A, Tripathy JP, Smith KR, Bates MN, et al. Household air pollution and stillbirths
in India: analysis of the DLHS-II national survey. Environmental research. 2013;121:17-22.
26. Lavigne E, Yasseen III AS, Stieb DM, Hystad P, Van Donkelaar A, Martin RV, et al. Ambient air pollution and adverse birth outcomes: differences by maternal comorbidities Environmental research. 2016;148:457-66.
27. Morokuma S, Michikawa T, Yamazaki S, Nitta H, Kato K. Association between exposure to air pollution during
pregnancy and false positives in fetal heart rate monitoring. Scientific reports. 2017;7(1):12421.
28. Neogi SB, Pandey S, Sharma J, Chokshi M, Chauhan M, Zodpey S, et al. Association between household air
pollution sand neonatal mortality: an analysis of annual health survey results, India. WHO South-East Asia journal of public health. 2015;4(1):30.
29. Rogers JF, Thompson SJ, Addy CL, McKeown RE, Cowen DJ, Decoufle P. Association of very low birth
weight with exposures to environmental sulfur dioxide and total suspended particulates. American journal of epidemiology. 2000;151(6):602-13.
30. Seeni I, Ha S, Nobles C, Liu D, Sherman S, Mendola P. Air pollution exposure during pregnancy: maternal
asthma and neonatal respiratory outcomes. Annals of epidemiology. 2018;28(9):612-8.
31. Soh SE, Goh A, Teoh OH, Godfrey KM, Gluckman PD, Shek LP, et al. Pregnancy trimester-specific exposure
to ambient air pollution and child respiratory health outcomes in the first 2 years of life: Effect modification by maternal pre-pregnancy BMI. International journal of environmental research and public health.
2018;15(5):996.
32. Son JY, Lee HJ, Koutrakis P, Bell ML. Pregnancy and lifetime exposure to fine particulate matter and infant mortality in Massachusetts, 2001-2007. American journal of epidemiology. 2017;186(11):1268-76.
33. Song J, Chen Y, Wei L, Ma Y, Tian N, Huang SY, et al. Early-life exposure to air pollutants and adverse
pregnancy outcomes: protocol for a prospective cohort study in Beijing. BMJ open. 2017;7(9):e015895.
34. Tanwar V, Gorr MW, Velten M, Eichenseer CM, Long III VP, Bonilla IM, et al. In utero particulate matter exposure
produces heart failure, electrical remodeling, and epigenetic changes at adulthood. Journal of the
American heart association. 2017;6(4):e005796.
35. Tielsch JM, Katz J, Thulasiraj RD, Coles CL, Sheeladevi S, Yanik EL, et al. Exposure to indoor biomass fuel and tobacco smoke and risk of adverse reproductive outcomes, mortality, respiratory morbidity and growth among newborn infants in south India. International journal of epidemiology. 2009;38(5):1351-63.
36. Van den Eeden L, Lambrechts N, Verheyen V, Berth M, Schoeters G, Jacquemyn Y. Impact of particulate matter
on mothers and babies in Antwerp (IPANEMA): a prospective cohort study on the impact of pollutants and particulate matter in pregnancy. BMJ open. 2018;8(3):e020028.
37. Winckelmans E, Cox B Martens E, Fierens F, Nemery B, Nawrot TS. Fetal growth and maternal exposure to particulate air pollution--More marked effects at lower exposure and modification by gestational duration. Environmental
research. 2015;140:611-8.
38. Wu J, Wilhelm M, Chung J, Ritz B. Comparing expoin an adverse pregnancy outcome study. Environmental research. 2011;111(5):685-92.
39. Xiao Q, Chen H, Strickland MJ, Kan H, Chang HH, Klein M, et al. Associations between birth outcomes and maternal PM2.5 exposure in Shanghai: A comparison of three exposure assessment approaches. Environment international. 2018;117:226-36.
40. Yorifuji T, Tsukahara H, Kashima S, Doi H. Intrauterine and early postnatal exposure to particulate air pollution
and kawasaki disease: A nationwide longitudinal survey in Japan. The Journal of pediatrics. 2018;193:147-54.
41. Zhang Q, Xiang XM, Song H, Dong M, Zhang SP, Mi BB, et al. Relationship between exposure to air pollutants during pre-pregnancy or early pregnancy and birth defects in Xi’an, 2013-2015: a case crossover study. Zhonghua liu xing bing xue za zhi=Zhonghua liuxingbingxue zazhi. 2017;38(12):1677-82.
42. Zhang M, Mueller NT, Wang H, Hong X, Appel LJ, Wang X. Maternal exposure to ambient particulate matter≤ 2.5 μm during pregnancy and the risk for high blood pressure in childhood. Hypertension. 2018;72(1):194-
201.
43. Zhu Y, Zhang C, Liu D, Grantz KL, Wallace M, Mendola P. Maternal ambient air pollution exposure preconception
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macrophages. Environmental toxicology and pharmacology. 2014;38(2):518-30.
2. EPA (Environmental Protection Agency). A decade of children’s environmental health research: highlights
from EPA’s science to achieve results program. Office of research and development, U.S.; Washington, DC.
3. Møller P, Danielsen PH, Karottki DG, Jantzen K, Roursgaard M, Klingberg H, et al. Oxidative stress and inflammation generated DNA damage by exposure to air pollution particles. Mutation research/Reviews inmutation research. 2014; 762:133-66.
4. Cao Z, Meng L, Zhao Y, Liu C, Yang Y, Su X, et al. Maternal exposure to ambient fine particulate matter and
fetal growth in Shanghai, China. Environmental health. 2019;18(1):49.
5. Alderete TL, Song AY, Bastain T, Habre R, Toledo‐Corral CM, Salam MT, et al. Prenatal traffic‐related air pollution exposures, cord blood adipokines and infant weight. Pediatric obesity. 2018;13(6):348-56.
6. Balakrishnan K, Sambandam S, Ramaswamy P, Ghosh S, Venkatesan V, Thangavel G, et al. Establishing integrated rural–urban cohorts to assess air pollutionrelated health effects in pregnant women, children and adults in Southern India: an overview of objectives, design and methods in the Tamil Nadu air pollution and health effects (TAPHE) study. BMJ open. 2015;5(6): e008090.
7. Balakrishnan K, Ghosh S, Thangavel G, Sambandam S, Mukhopadhyay K, Puttaswamy N, et al. Exposures
to fine particulate matter (PM2.5) and birthweight in a rural-urban, mother-child cohort in Tamil Nadu, India. Environmental research. 2018;161:524-31.
8. Basu R, Pearson D, Ebisu K, Malig B. Association between PM2.5 and PM2.5 constituents and preterm delivery in California, 2000–2006. Paediatric and perinatal epidemiology. 2017;31(5):424-34.
9. Brauer M, Lencar C, Tamburic L, Koehoorn M, Demers P, Karr C. A cohort study of traffic-related air pollution
impacts on birth outcomes. Environmental health perspectives. 2008;116(5):680-6.
10. Bunkar N, Bhargava A, Chaudhury K, Sharma RS, Lohiya NK, Mishra PK. Fetal nucleic acids in maternal
plasma: from biology to clinical translation. Frontiers in Bioscience. 2018; 23:397-431.
11. Choe SA, Jun YB, Lee WS, Yoon TK, Kim SY. Association between ambient air pollution and pregnancy rate
in women who underwent IVF. Human reproduction. 2018;33(6):1071-8.
12. Conde PG, Farhat L LC, Braga AL, Sallum AE, Farhat SC, Silva CA. Are prematurity and environmental factors
determinants for developing childhood-onset systemic
lupus erythematosus? Modern rheumatology. 2018;28(1):156-60.
13. Contreras ZA, Heck JE, Lee PC, Cui X, Hobel CJ, Janzen C, et al. Prenatal air pollution exposure, smoking, and uterine vascular resistance. Environmental epidemiology (Philadelphia, Pa.). 2018;2(3).
14. Dodd-Butera T, Quintana PJ, Ramirez-Zetina M, Batista- Castro AC, Sierra MM, Shaputnic C, et al. Placental biomarkers of PAH exposure and glutathione-S-transferase biotransformation enzymes in an obstetric population from Tijuana, Baja California, Mexico. Environmental research. 2017;152:360-8.
15. Ebisu K, Malig B, Hasheminassab S, Sioutas C, Basu R. Cause-specific stillbirth and exposure to chemical constituents and sources of fine particulate matter. Environmental research. 2018;160: 358-64.
16. Gehring U, Tamburic L, Sbihi H, Davies HW, Brauer M. Impact of noise and air pollution on pregnancy outcomes.
Epidemiology. 2014;25(3):351-8.
17. Stieb DM, Chen L, Eshoul M, Judek S. Ambient air pollution, birth weight and preterm birth: a systematic
review and meta-analysis. Environmental research. 2012;117:100-11.
18. Golan R, Kloog I, Almog R, Gesser-Edelsburg A, Negev M, Jolles M, et al. Environmental exposures and
fetal growth: The Haifa pregnancy cohort study. BMC public health. 2018;18(1):132.
19. Guo LQ, Zhang Q, Zhao DD, Wang LL, Chen Y, Mi BB, et al. Relationship between air pollution exposure during
pregnancy and birth weight of term singleton livebirth newborns. Zhonghua liu xing bing xue za zhi= Zhonghua liuxingbingxue zazhi. 2017;38(10):1399- 403.
20. Guo T, Wang Y, Zhang H, Zhang Y, Zhao J, Wang Q, et al. The association between ambient PM2.5 exposure
and the risk of preterm birth in China: A retrospective cohort study. Science of the total environment. 2018;633:1453-9.
21. Ha S, Sundaram R, Louis GM, Nobles C, Seeni I, Sherman S, et al. Ambient air pollution and the risk of pregnancy loss: a prospective cohort study. Fertility and sterility. 2018;109(1):148-53.
22. Johnson S, Bobb JF, Ito K, Savitz DA, Elston B, Shmool JL, et al. Ambient fine particulate matter, nitrogen dioxide,
and preterm birth in New York city. Environmental health perspectives. 2016;124(8):1283-90.
23. Kingsley SL, Eliot MN, Glazer K, Awad YA, Schwartz JD, Savitz DA, et al. Maternal ambient air pollution, preterm
birth and markers of fetal growth in Rhode Island: results of a hospital-based linkage study. Journal of epidemiology
and community health. 2017;71(12):1131-6.
24. La Marca L, Gava G. Air Pollution Effects in Pregnancy. In: Clinical handbook of air pollution-related diseases 2018:479-494 Springer, Cham.
25. Lakshmi PV, Virdi NK, Sharma A, Tripathy JP, Smith KR, Bates MN, et al. Household air pollution and stillbirths
in India: analysis of the DLHS-II national survey. Environmental research. 2013;121:17-22.
26. Lavigne E, Yasseen III AS, Stieb DM, Hystad P, Van Donkelaar A, Martin RV, et al. Ambient air pollution and adverse birth outcomes: differences by maternal comorbidities Environmental research. 2016;148:457-66.
27. Morokuma S, Michikawa T, Yamazaki S, Nitta H, Kato K. Association between exposure to air pollution during
pregnancy and false positives in fetal heart rate monitoring. Scientific reports. 2017;7(1):12421.
28. Neogi SB, Pandey S, Sharma J, Chokshi M, Chauhan M, Zodpey S, et al. Association between household air
pollution sand neonatal mortality: an analysis of annual health survey results, India. WHO South-East Asia journal of public health. 2015;4(1):30.
29. Rogers JF, Thompson SJ, Addy CL, McKeown RE, Cowen DJ, Decoufle P. Association of very low birth
weight with exposures to environmental sulfur dioxide and total suspended particulates. American journal of epidemiology. 2000;151(6):602-13.
30. Seeni I, Ha S, Nobles C, Liu D, Sherman S, Mendola P. Air pollution exposure during pregnancy: maternal
asthma and neonatal respiratory outcomes. Annals of epidemiology. 2018;28(9):612-8.
31. Soh SE, Goh A, Teoh OH, Godfrey KM, Gluckman PD, Shek LP, et al. Pregnancy trimester-specific exposure
to ambient air pollution and child respiratory health outcomes in the first 2 years of life: Effect modification by maternal pre-pregnancy BMI. International journal of environmental research and public health.
2018;15(5):996.
32. Son JY, Lee HJ, Koutrakis P, Bell ML. Pregnancy and lifetime exposure to fine particulate matter and infant mortality in Massachusetts, 2001-2007. American journal of epidemiology. 2017;186(11):1268-76.
33. Song J, Chen Y, Wei L, Ma Y, Tian N, Huang SY, et al. Early-life exposure to air pollutants and adverse
pregnancy outcomes: protocol for a prospective cohort study in Beijing. BMJ open. 2017;7(9):e015895.
34. Tanwar V, Gorr MW, Velten M, Eichenseer CM, Long III VP, Bonilla IM, et al. In utero particulate matter exposure
produces heart failure, electrical remodeling, and epigenetic changes at adulthood. Journal of the
American heart association. 2017;6(4):e005796.
35. Tielsch JM, Katz J, Thulasiraj RD, Coles CL, Sheeladevi S, Yanik EL, et al. Exposure to indoor biomass fuel and tobacco smoke and risk of adverse reproductive outcomes, mortality, respiratory morbidity and growth among newborn infants in south India. International journal of epidemiology. 2009;38(5):1351-63.
36. Van den Eeden L, Lambrechts N, Verheyen V, Berth M, Schoeters G, Jacquemyn Y. Impact of particulate matter
on mothers and babies in Antwerp (IPANEMA): a prospective cohort study on the impact of pollutants and particulate matter in pregnancy. BMJ open. 2018;8(3):e020028.
37. Winckelmans E, Cox B Martens E, Fierens F, Nemery B, Nawrot TS. Fetal growth and maternal exposure to particulate air pollution--More marked effects at lower exposure and modification by gestational duration. Environmental
research. 2015;140:611-8.
38. Wu J, Wilhelm M, Chung J, Ritz B. Comparing expoin an adverse pregnancy outcome study. Environmental research. 2011;111(5):685-92.
39. Xiao Q, Chen H, Strickland MJ, Kan H, Chang HH, Klein M, et al. Associations between birth outcomes and maternal PM2.5 exposure in Shanghai: A comparison of three exposure assessment approaches. Environment international. 2018;117:226-36.
40. Yorifuji T, Tsukahara H, Kashima S, Doi H. Intrauterine and early postnatal exposure to particulate air pollution
and kawasaki disease: A nationwide longitudinal survey in Japan. The Journal of pediatrics. 2018;193:147-54.
41. Zhang Q, Xiang XM, Song H, Dong M, Zhang SP, Mi BB, et al. Relationship between exposure to air pollutants during pre-pregnancy or early pregnancy and birth defects in Xi’an, 2013-2015: a case crossover study. Zhonghua liu xing bing xue za zhi=Zhonghua liuxingbingxue zazhi. 2017;38(12):1677-82.
42. Zhang M, Mueller NT, Wang H, Hong X, Appel LJ, Wang X. Maternal exposure to ambient particulate matter≤ 2.5 μm during pregnancy and the risk for high blood pressure in childhood. Hypertension. 2018;72(1):194-
201.
43. Zhu Y, Zhang C, Liu D, Grantz KL, Wallace M, Mendola P. Maternal ambient air pollution exposure preconception
and during early gestation and offspring congenital orofacial defects. Environmental research. 2015;140:714-20.
44. Jain KK. Carbon monoxide and other tissue poisons. In: Textbook of hyperbaric medicine 2017;131-154. Springer, Cham.
45. Queiroga CS, Almeida AS, Vieira HL. Carbon monoxide targeting mitochondria. Biochemistry research international.
2012;2012.
46. Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT. Carbon monoxide poisoning: pathogenesis,
management, and future directions of therapy. American journal of respiratory and critical care medicine.
2017;195(5):596-606.
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| Files | ||
| Issue | Vol 4 No 3 (2019): Summer 2019 | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/japh.v4i3.1549 | |
| Keywords | ||
| Fetal development; Maternal health; Prenatal exposure; Reproductive health | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Kashyap R, Gupta R, Mansuri MA, Thasale R, Rathod Z, Patni R. A review on effect of air pollutants on fetal development and pregnancy outcomes. JAPH. 2019;4(3):193-208.
