Journal of Air Pollution and Health 2016. 1(2):123-136.

CRITICAL REVIEW OF AIR POLLUTION HEALTH EFFECTS WITH SPECIAL CONCERN ON RESPIRATORY HEALTH
Morteza Abdullatif Khafaie, Chittaranjan S Yajnik, Sundeep S Salvi, Ajay Ojha

Abstract


Searching, PubMed (accessed Nov. 10, 2015) for “Air pollution” and “Health” resulted in 26,156 citations. Since the 1930 Meuse Valley episode in Belgium, Donora 1948 and the London fog of December 1952, the number of studies showing adverse health effects of short and long term exposure to outdoor air pollution has grown. This review looks at historical air pollution studies to get a general overview of the overall health effects that can be attributed to bad air quality. Then we specifically reviewed the important respiratory effects, the plausible mechanism and population at greater risk. Further research is central concern of researcher and policy maker to assess the plausible biological mechanisms of air pollution effects and identifying specific air pollutant that would be more dangerous

Keywords


air pollution; health effect; mechanism; respiratory system

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Nemery B, Hoet PH, Nemmar A. The Meuse Valley fog of 1930: an air pollution disaster. The Lancet. 2001;357(9257):704-8.

Helfand WH, Lazarus J, Theerman P. Donora, Pennsylvania: an environmental disaster of the 20th century. American journal of public health. 2001;91(4):553.

Bell ML, Davis DL. Reassessment of the lethal London fog of 1952: novel indicators of acute and chronic consequences of acute exposure to air pollution. Environmental health perspectives. 2001;109(Suppl 3):389-94.

Bucher JR. Methyl isocyanate: A review of health effects research since Bhopal. Fundamental and Applied Toxicology. 1987;9(3):367-379.

Mazzoli-Rocha F, Fernandes S, Einicker-Lamas M, Zin WA. Roles of oxidative stress in signaling and inflammation induced by particulate matter. Cell biology and toxicology. 2010;26(5):481-98.

Alexandra S, Lucas N, Margaret CH, Martin C, Ronald WW, Wayne CA, et al. Endothelial Dysfunction: Associations with Exposure to Ambient Fine Particles in Diabetic Individuals. Environmental Health Perspectives. 2008;116(12):1666–1674.

Franchini M, Mannucci PM. Thrombogenicity and cardiovascular effects of ambient air pollution. Blood. 2011;118(9):2405-12.

Mutlu GM, Bryce PJ, Budinger GRS. Linking air pollution exposure with thrombosis. Blood. 2011;118(9):2636-7.

Link MS, Dockery DW. Air pollution and the triggering of cardiac arrhythmias. Current opinion in cardiology 2010;25(1):16-22.

Hoffmann B, Luttmann-Gibson H, Cohen A, Zanobetti A, de Souza C, Foley C, et al. Opposing effects of particle pollution, ozone and ambient temperature on arterial blood pressure. Environmental health perspectives. 2012;120(2):241-46.

Gomez-Mejiba SE, Zhai Z, Akram H, Pye QN, Hensley K, Kurien BT, et al. Inhalation of environmental stressors & chronic inflammation: autoimmunity and neurodegeneration. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2009;674(1):62-72.

Sun Q, Yue P, Deiuliis J, Lumeng C, Kampfrath T, Mikolaj M, et al. Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation. 2009. 2009;119(4):538-46.

Brook RD, Jerrett M, Brook JR, Bard RL, Finkelstein MM. The relationship between diabetes mellitus and traffic-related air pollution. Journal of Occupational and Environmental Medicine / American College of Occupational and Environmental Medicine 2008;50(1):32-8.

Marquez EB, Diaz BR, Gurian PL. Understanding the associations between statewide diabetes prevalence and air pollution emissions. Diabetes care 2004;27(6):1515-7.

Lockwood AH. Diabetes and air pollution. Diabetes care 2002;25(8):1487-8.

Ristovski ZD, Miljevic B, Surawski NC, Morawska L, Fong KM, Goh F, et al. Respiratory health effects of diesel particulate matter. Respirology (Carlton, Vic.). 2012;17(2):201-12.

van Eeden SF, Yeung A, Quinlam K, Hogg JC. Systemic response to ambient particulate matter: relevance to chronic obstructive pulmonary disease. Proceedings of the American Thoracic Society. 2005;2(1):61-7.

Sun Q, Hong X, Wold LE. Cardiovascular effects of ambient particulate air pollution exposure. Circulation. 2010;121(25):2755-65.

Fann N, Lamson AD, Anenberg SC, Wesson K, Risley D, Hubbell BJ. Estimating the National Public Health Burden Associated with Exposure to Ambient PM2.5 and Ozone. Risk analysis : an official publication of the Society for Risk Analysis. 2012;32(1):81-95.

Pope CA, 3rd, Dockery DW. Health effects of fine particulate air pollution: lines that connect. Journal of Air and Waste Management Association. 2006;56(6):709-42.

Dominici F, McDermott A, Zeger SL, Samet JM. National maps of the effects of particulate matter on mortality: exploring geographical variation. Environ Health Perspect 2003;111(1):39-44.

Peng RD, Dominici F, Pastor-Barriuso R, Zeger SL, Samet JM. Seasonal analyses of air pollution and mortality in 100 US cities. American Journal of Epidemiology. 2005;161(6):585-94.

Samet Jm Fau - Dominici F, Dominici F Fau - Curriero FC, Curriero Fc Fau - Coursac I, Coursac I Fau - Zeger SL, Zeger SL. Fine particulate air pollution and mortality in 20 US cities, 1987-1994. New England Journal of Medicine. 2000;343(24):1742-9.

Dominici F, Peng RD, Ebisu K, Zeger SL, Samet JM, Bell ML. Does the effect of PM10 on mortality depend on PM nickel and vanadium content? A reanalysis of the NMMAPS data. Environmental Health Perspective. 2007;115(12):1701-3.

Analitis A, Katsouyanni K, Dimakopoulou K, Samoli E, Nikoloulopoulos AK, Petasakis Y, et al. Short-term effects of ambient particles on cardiovascular and respiratory mortality. Epidemiology. 2006;17(2):230-3.

Katsouyanni K. Ambient air pollution and health. British Medical Bulletin. 2003;68(1):143-56.

Omori T, Fujimoto G, Yoshimura I, Nitta H, Ono M. Effects of particulate matter on daily mortality in 13 Japanese cities. Journal of Epidemiology. 2003;13(6):314-22.

Wong CM, Vichit-Vadakan N, Kan H, Qian Z. Public Health and Air Pollution in Asia (PAPA): a multicity study of short-term effects of air pollution on mortality. Environmental Health Perspectives. 2008;116(9):1195-202.

Pope CA, Muhlestein JB, May HT, Renlund DG, Anderson JL, Horne BD. Ischemic heart disease events triggered by short-term exposure to fine particulate air pollution. Circulation. 2006;114(23):2443-8.

Dominici F. Time-series analysis of air pollution and mortality: a statistical review. Research report (Health Effects Institute). 2004(123):3-27; discussion 29-33.

Cropper ML, Simon NB, Alberini A, Sharma P. The health effects of air pollution in Delhi, India. World Bank Policy Research WorkingPaper. 1997(1860).

Dominici F, Peng RD, Bell ML, Pham L, McDermott A, Zeger SL, et al. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. Jama. 2006;295(10):1127-34.

Brook RD, Rajagopalan S, Pope CA, Brook JR, Bhatnagar A, Diez-Roux AV, et al. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation. 2010;121(21):2331-78.

Lave LB, Seskin EP. Air pollution and human health. Science 1970;169(3947):723-33.

Evans JS, Tosteson T, Kinney PL. Cross-sectional mortality studies and air pollution risk assessment. Environment international. 1984;10(1):55-83.

McMichael AJ, Anderson HR, Brunekreef B, Cohen AJ. Inappropriate use of daily mortality analyses to estimate longer-term mortality effects of air pollution. International Journal of Epidemiology. 1998;27(3):450-3.

Wiwanitkit V, Suwansaksri J, Soogarun S. Cancer risk for Thai traffic police exposed to traffic benzene vapor. Asian Pac J Cancer Prev. 2005;6(2):219-20.

Laden F, Schwartz J, Speizer FE, Dockery DW. Reduction in fine particulate air pollution and mortality: Extended follow-up of the Harvard Six Cities study. American Journal of Respiratory and Critical Care Medicine. 2006;173(6):667-72.

`Andersen ZJ, Raaschou-Nielsen O, Ketzel M, Jensen SS, Hvidberg M, Loft S, et al. Diabetes incidence and long-term exposure to air pollution: a cohort study. Diabetes care. 2012;35(1):92-8.

Bates ML, Bascom R. Air Pollution and the Pulmonary Vasculature. Textbook of Pulmonary Vascular Disease: Springer; 2011. p. 963-77.

Laumbach RJ, Kipen HM. Respiratory health effects of air pollution: Update on biomass smoke and traffic pollution. Journal of Allergy and Clinical Immunology. 2012;129(1):3-11.

Sin D, Wu L, Man S. The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature. CHEST Journal. 2005;127(6):1952–59.

Pope Cr, Dockery D. Health effects of fine particulate air pollution: lines that connect. Journal of the Air Waste Management Association. 2006;56(6):709–42.

Dockery D, Speizer F, Stram D, Ware J, Spengler J, Ferris BJ. Effects of inhalable particles on respiratory health of children. American Review of Respiratory Disease. 1989;139(3):587-594.

Schwartz J. Lung function and chronic exposure to air pollution: a cross-sectional analysis of NHANES II. Environmental Research. 1989;50(2):309-21.

Peters J, Avol E, Gauderman W. A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. American Journal of Respiratory and Critical Care Medicine. 1999;159(3):768-75.

Khafaie A. M, Salvi SS, Khafaie B, Ojha A, Yajnik CS. The impact of air pollution on respiratory health among diabetes and non-diabetes subject in Pune, India. Environment and Health—Bridging South, North, East and West. Environmental Health Perspective; .2013: p. P-1-25-16.

Frischer T, Studnicka M, GARTNER C, Tauber E, Horak F, Veiter A, et al. Lung function growth and ambient ozone: a three-year population study in school children. American journal of respiratory and critical care medicine. 1999;160(2):390-6.

Jedrychowski W, Flak E, Mróz E. The adverse effect of low levels of ambient air pollutants on lung function growth in preadolescent children. Environmental Health Perspectives. 1999;107(8):669-74.

Horak FJ, Studnicka M, Gartner C. Particulate matter and lung function growth in children: a 3-yr follow-up study in Austrian schoolchildren. European Respiratory Journal. 2002;19(5):838-45.

Gauderman WJ, Gilliland GF, Vora H, Avol E, Stram D, McConnell R, et al. Association between air pollution and lung function growth in southern California children: results from a second cohort. Am J Respir Crit Care Med 2002;166(1):76-84.

Avol EL, Gauderman WJ, Tan SM, London SJ, Peters JM. Respiratory effects of relocating to areas of differing air pollution levels. American Journal of Respiratory and Critical Care Medicine. 2001;164(11):2067-72.

Gauderman WJ, Avol E, Gilliland F, Vora H, Thomas D, Berhane K, et al. The effect of air pollution on lung development from 10 to 18 years of age. New England Journal of Medicine. 2004;351(11):1057-67.

Ackermann-Liebrich U, Leuenberger P, Schwartz J, Schindler C, Monn C, Bolognini G, et al. Lung function and long term exposure to air pollutants in Switzerland. Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. American journal of respiratory

and critical care medicine. 1997;155(1):122-9.

Schikowski T, Sugiri D, Ranft U, Gehring U, Heinrich J, Wichmann H-E, et al. Long-term air pollution exposure and living close to busy roads are associated with COPD in women. Respir Res. 2005;6(1):152.

Downs SH, Brändli O, Zellweger J-P, Schindler C, Künzli N, Gerbase MW, et al. Accelerated decline in lung function in smoking women with airway obstruction: SAPALDIA 2 cohort study. Respiratory research. 2005;6(1):45.

van der Lende R, Kok T, Peset R, Quanjer P, Schouten J, Orie N. Longterm exposure to air pollution and decline in VC and FEV1: Recent results from a longitudinal epidemiologic study in the Netherlands. CHEST Journal. 1981;80(1- Supplement):23S–26S.

Tashkin D, Detels R, Simmons M, Liu H, Coulson AH, Sayre J, et al. The UCLA population studies of chronic obstructive respiratory disease: XI. Impact of air pollution and smoking on annual change in forced expiratory volume in one second. American Journal of Respiratory and Critical Care Medicine. 1994;149(5):1209–17.

Sekine K, Shima M, Nitta Y, Adachi M. Long term effects of exposure to automobile exhaust on the pulmonary function of female adult in Tokyo, Japan. Occupational Environmental Medicine. 2004;61(4):350–7.

Jedrychowski W, Krzyzanowski M. Ventilatory lung function and chronic chest symptoms among the inhabitants of urban areas with various levels of acid aerosols: prospective study in Cracow. Environmental Health Perspectives. 1989;79:101–7.

Götschi T, Sunyer J, Chinn S, de Marco R, Forsberg B, Gauderman JW, et al. Air pollution and lung function in the European Community Respiratory Health Survey. International journal of epidemiology. 2008;37(6):1349-58.

Künzli N, Ackermann-Liebrich U, Brändli O, Tschopp J, Schindler C, Leuenberger P, et al. Clinically “small” effects of air pollution on FVC have a large public health impact. Eur Respir J. 2000;15(1):131-6.

Downs SH, Schindler C, Liu LJ, Keidel D, Bayer-Oglesby L, Brutsche MH, et al. Reduced exposure to PM10 and attenuated age-related decline in lung function. New England Journal of Medicine. 2007;357(23):2338-47.

Nuvolone D, Della Maggiore R, Maio S, Fresco R, Baldacci S, Carrozzi L, et al. Geographical information system and environmental epidemiology: a crosssectional spatial analysis of the effects of traffic-related air pollution on population respiratory health. Environ Health. 2011;10(1):12.

Forbes LJL, Kapetanakis V, Rudnicka AR, Cook DG, Bush T, Stedman JR, et al. Chronic exposure to outdoor air pollution and lung function in adults. Thorax. 2009;64(8):657–63.

He Q, Wong T, Du L, Jiang Z, Gao Y, Qiu H, et al. Effects of ambient air pollution on lung function growth in Chinese schoolchildren. Respiratory Medicine. 2010;104(10):1512-20.

Dockery DW, Cunningham J, Damokosh AI, Neas LM, Spengler JD, Koutrakis P, et al. Health effects of acid aerosols on North American children: respiratory symptoms. Environmental Health Perspectives. 1996;104(5):500-5.

Braun-Fahrländer C, Vuille JC, Sennhauser FH, Neu U, Künzle T, Grize L, et al. Respiratory health and longterm exposure to air pollutants in Swiss schoolchildren. SCARPOL Team. Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution, Climate and Pollen. American Journal of Respiratory and Critical Care Medicine. 1997;155(3):1042-9.

Studnicka M, Hackl E, Pischinger J, Fangmeyer C, Haschke N, Kuhr J, et al. Traffic-related NO2 and the prevalence of asthma and respiratory symptoms in seven year olds. European Respiratory Journal. 1997;10(10):2275-8.

Stern B, Jones L, Raizenne M, Burnett R, Meranger JC, Franklin CA. Respiratory health effects associated with ambient sulfates and ozone in two rural Canadian communities. Environmental Research. 1989;49(1):20-39.

Brauer M, Hoek G, Vliet PV, Meliefste K, Fischer PH, Wijga A, et al. Air Pollution from Traffic and the Development of Respiratory Infections and Asthmatic and Allergic Symptoms in Children. American Journal of Respiratory and Critical Care Medicine. 2002;166(8):1092-8.

McConnell R, Berhane K, Gilliland F, London S, Islam T, Gauderman W, et al. Asthma in exercising children exposed to ozone: a cohort study. The Lancet 2002;359(9304):386-91.

Schikowski T, Sugiri D, Ranft U, Gehring U, Heinrich J, Wichmann H-E, et al. Long-term air pollution exposure and living close to busy roads are associated with COPD in women. Respir Res. 2005;6(1):152.

Brauer M, Hoek G, Smit H, De Jongste J, Gerritsen J, Postma DS, et al. Air pollution and development of asthma, allergy and infections in a birth cohort. European Respiratory Journal. 2007;29(5):879–88.

Morgenstern V, Zutavern A, Cyrys J, Brockow I, Koletzko S, Krämer U, et al. Atopic Diseases, allergic sensitization, and exposure to traffic-related air pollution in children. American Journal of Respiratory and Critical Care Medicine. 2008;177(12):1331-7.

Nordling E, Berglind N, Melén E, Emenius G, Hallberg J, Nyberg F, et al. Traffic-related air pollution and childhood respiratory symptoms, function and allergies. Epidemiology. 2008;19 (3):401-8.

Andersen ZJ, Hvidberg M, Jensen SS, Ketzel M, Loft S, Sorensen M, et al. Chronic Obstructive Pulmonary Disease and Long-Term Exposure to Traffic-related Air Pollution. American Journal of Respiratory and Critical Care Medicine 2011;183(4):455-61.

Gehring U, Wijga AH, Brauer M, Fischer P, de Jongste JC, Kerkhof M, et al. Traffic-related Air Pollution and the Development of Asthma and Allergies during the First 8 Years of Life. American Journal of Respiratory and Critical Care Medicine. 2010;181(6):596-603.

Ware J, Ferris Jr B, Dockery D, Spengler J, Stram D, Speizer FE. Effects of ambient sulfur oxides and suspended particles on respiratory health of preadolescent children. The American Review of Respiratory Disease. 1986;133(5):834-42.

Raizenne M, Neas LM, Damokosh A, Dockery DW, Spengler JD, Koutrakis P, et al. Health effects of acid aerosols on North American children: pulmonary function. Environmental Health Perspectives.

;104(5):506-514.

Li N, Wang M, Oberley TD, Sempf JM, Nel AE. Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages. The Journal of Immunology. 2002;169(8):4531-41.

Happo M, Salonen R, Hälinen A, Jalava P, Pennanen A, Dormans J, et al. Inflammation and tissue damage in mouse lung by single and repeated dosing of urban air coarse and fine particles collected from six European cities. Inhalation toxicology. 2010;22(5):402-16.

Sørensen M, Daneshvar B, Hansen M, Dragsted LO, Hertel O, Knudsen L, et al. Personal PM2.5 exposure and markers of oxidative stress in blood. Environmental Health Perspectives. 2003;111(2):161-6.

Becker S, Mundandhara S, Devlin RB, Madden M. Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studies. Toxicology and Applied Pharmacology.

;207(2):269-75.

Goldsmith C-AW, Ning Y, Qin G, Imrich A, Lawrence J, Murthy GK, et al. Combined air pollution particle and ozone exposure increases airway responsiveness in mice. Inhalation Toxicology. 2002;14(4):325-47.

Imrich C-AWGA, Ning HDY. Analysis of air pollution particulate-mediated oxidant stress in alveolar macrophages. Journal of Toxicology and Environmental Health Part A. 1998;54(7):529-45.

Ghio AJ, Kim C, Devlin RB. Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. American Journal of Respiratory and Critical Care Medicine. 2000;162(3):981-8.

van EEDEN SF, Tan WC, Suwa T, Mukae H, Terashima T, Fujii T, et al. Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM10). American Journal of Respiratory and Critical Care Medicine. 2001;164(5):826-30.

Mills NL, Donaldson K, Hadoke PW, Boon NA, Mac-Nee W, Cassee FR, et al. Adverse cardiovascular effects of air pollution. Nature clinical practice. Cardiovascular Medicine. 2009;6(1):36-44.

Brook RD, Urch B, Dvonch JT, Bard RL, Speck M, Keeler G, et al. Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans. Hypertension. 2009;54(3):659-67.

Clark ML, Peel JL, Burch JB, Nelson TL, Robinson MM, Conway S, et al. Impact of improved cookstoves on indoor air pollution and adverse health effects among Honduran women. International Journal of Environmental Health Research. 2009;19(5):357-68.

Delfino RJ, Staimer N, Gillen D, Tjoa T, Sioutas C, Fung K, et al. Personal and ambient air pollution is associated with increased exhaled nitric oxide in children with asthma. Environmental Health Perspectives. 2006;114(11):1736-43.

Seatona A, Soutara A, Crawfordb V, Eltonc R, McNerlanb S, Cherriea J, et al. Particulate air pollution and the blood. Thorax. 1999;54(11):1027-32.

Peters A, Frohlich M, Doring A, Immervoll T, Wichmann H-E, Hutchinson W, et al. Particulate air pollution is associated with an acute phase response in men; results from the MONICA-Augsburg Study. European Heart Journal. 2001;22(14):1198-204.

Riediker M, Cascio WE, Griggs TR, Herbst MC, Bromberg PA, Neas L, et al. Particulate matter exposure in cars is associated with cardiovascular effects in healthy young men. American Journal of Respiratory and Critical Care Medicine. 2004;169(8):934-40.

Pope Iii CA, Hansen ML, Long RW, Nielsen KR, Eatough NL, Wilson WE, et al. Ambient particulate air pollution, heart rate variability, and blood markers of inflammation in a panel of elderly subjects. Environmental Health Perspectives. 2004;112(3):339-45.

Rückerl R, Ibald-Mulli A, Koenig W, Schneider A, Woelke G, Cyrys J, et al. Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. American Journal of Respiratory and Critical Care Medicine. 2006;173(4):432-441.

Roux AVD, Auchincloss AH, Astor B, Barr RG, Cushman M, Dvonch T, et al. Recent exposure to particulate matter and C- reactive protein concentration in the multi-ethnic study of atherosclerosis. American Journal of Epidemiology. 2006;164(5):437-48.

Zeka A, Sullivan JR, Vokonas PS, Sparrow D, Schwartz J. Inflammatory markers and particulate air pollution: characterizing the pathway to disease. International Journal of Epidemiology. 2006;35(5):1347-54.

Ruckerl R, Phipps RP, Schneider A, Frampton M, Cyrys J, Oberdorster G, et al. Ultrafine particles and platelet activation in patients with coronary heart disease-- results from a prospective panel study. Particle and Fibre Toxicology. 2007;4:1.

Chuang KJ, Chan CC, Su TC, Lee CT, Tang CS. The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults. American Journal of Respiratory and Critical Care Medicine. 2007;176(4):370-6.

Steinvil A, Kordova-Biezuner L, Shapira I, Berliner S, Rogowski O. Short-term exposure to air pollution and inflammation-sensitive biomarkers. Environmental Research. 2008;106(1):51-61.

Lee PC, Talbott EO, Roberts JM, Catov JM, Sharma RK, Ritz B. Particulate air pollution exposure and Creactive protein during early pregnancy. Epidemiology. 2011;22(4):524-31.

Khafaie MA, Salvi SS, Ojha A, Khafaie B, Gore SS, Yajnik CS. Systemic inflammation (C-reactive protein) in type 2 diabetic patients is associated with ambient air pollution in Pune City, India. Diabetes Care. 2013;36(3):625-30.

Kawasaki N, Asada R, Saito A, Kanemoto S, Imaizumi K. Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue. Scientific Reports. 2012;2.

Emanuela F, Grazia M, Marco de R, Maria Paola L, Giorgio F, Marco B. Inflammation as a Link between Obesity and Metabolic Syndrome. J Nutr Metab 2012;2012:476380.

Mancuso P. Obesity and lung inflammation. Journal

of Applied Physiology. 2010;108(3):722-8.


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