HEALTH RISK ASSESSMENT OF ATMOSPHERIC PARTICULATE-BOUND POLYCYCLIC AROMATIC HYDROCARBONS IN SHIRAZ, IRAN
Introduction: Benzo(a)pyren is an indicator of carcinogenic PAHs and enters the body through the respiratory system, gastrointestinal tract, and skin. This compound causes lung, kidney, and skin, cancers. In this study, the concentrations of PM10 and 16 PAHs compounds were measured in the particle phase in an urban and a suburban area of Shiraz and the carcinogenic risk of respiratory exposure to PAHs were assessed.
Materials and methods: A total of 60 samples were collected from Paramont and Sadra during spring 2015 using SKC sampling pump (for 24 h at a flow rate of 10 L/min). Dichloromethane/methanol mixture was used as a solvent. 16 PAHs were identificated using gas chromatography with mass spectrometry.
Results: The mean (±SD) concentrations of PM10 were 62.73±23.83 and 60.88±31.03 μg/m3 in the urban (Paramont) and suburban (Sadra) stations, respectively, which exceeded the PM10 emission limit value of the Europe Commission (50 μg/m3). Also, the mean concentrations (±SD) of the total PM10-bound PAHs were 19.28±7.48 ng/m3 and 17.80±9.17 ng/m3 in Paramont and Sadra stations, respectively. Besides, the BaPeq was 1.307 in Paramont and 0.814 in Sadra station. Incremental Lifetime Cancer Risk (ILCR) values for children below 10 years of age demonstrated the risk of cancer for this age group in both areas.
Conclusions: this study presented the value of PM10 and PAHs concentration in two sampling sites. The PM10 values were higher than Europe Commission and the PAHs concentrations could increase the potential risk of cancer among the children below 10 years old in both sampling areas.
Kakimoto K, Toriba A, Ohno T, Ueno M, Kameda T, Tang N, et al. Direct measurement of the glucuronide conjugate of 1-hydroxypyrene in human urine by using liquid chromatography with tandem mass spectrometry. Journal of Chromatography B. 2008;867(2):259-63.
Ramesh A, Walker SA, Hood DB, Guillén MD, Schneider K, Weyand EH. Bioavailability and risk assessment of orally ingested polycyclic aromatic hydrocarbons. International journal of toxicology. 2004;23(5):301-33.
Grainger J, Huang W, Patterson DG, Turner WE, Pirkle J, Caudill SP, et al. Reference range levels of polycyclic aromatic hydrocarbons in the US population by measurement of urinary monohydroxy metabolites. Environmental research. 2006;100(3):394-423.
Ramírez N, Cuadras A, Rovira E, Marcé RM, Borrull F. Risk assessment related to atmospheric polycyclic aromatic hydrocarbons in gas and particle phases near industrial sites. Environmental health perspectives. 2011;119(8):1110-1116.
Cancer IAfRo. Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures. IARC monographs on the evaluation of carcinogenic risks to humans. 2010;92:35-818.
Boström C-E, Gerde P, Hanberg A, Jernström B, Johansson
C, Kyrklund T, et al. Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air. Environmental health perspectives. 2002;110(Suppl 3):451–488.
Wang Y, Hu L, Lu G. Health risk analysis of atmospheric polycyclic aromatic hydrocarbons in big cities of China. Ecotoxicology. 2014;23(4):584-8.
Hoseini M, Yunesian M, Nabizadeh R, Yaghmaeian K, Ahmadkhaniha R, Rastkari N, et al. Characterization and risk assessment of polycyclic aromatic hydrocarbons (PAHs) in urban atmospheric Particulate of Tehran, Iran. Environmental Science and Pollution Research. 2016;23(2):1820-32.
Pufulete M, Battershill J, Boobis A, Fielder R. Approaches to carcinogenic risk assessment for polycyclic aromatic hydrocarbons: a UK perspective. Regulatory Toxicology and Pharmacology. 2004;40(1):54-66.
Moya J, Phillips L, Schuda L, Wood P, Diaz A, Lee R, et al. Exposure factors handbook. Washington: US Environmental Protection Agency; 2011.
US EPA. Risk assessment guidance for superfund. volume I: human health evaluation manual. Washington: Office of Superfund Remediation and Technology Innovation; 2004.
Chen S-C, Liao C-M. Health risk assessment on human exposed to environmental polycyclic aromatic hydrocarbons pollution sources. Science of the Total Environment. 2006;366(1):112-23.
Querol X, Alastuey A, Rodriguez S, Plana F, Ruiz CR, Cots N, et al. PM10 and PM2.5 source apportionment in the Barcelona Metropolitan area, Catalonia, Spain. Atmospheric Environment. 2001;35(36):6407-19.
Hueglin C, Gehrig R, Baltensperger U, Gysel M, Monn C, Vonmont H. Chemical characterisation of PM2.5, PM10 and coarse particles at urban, near-city and rural sites in Switzerland. Atmospheric Environment. 2005;39(4):637-51.
Padoan E, Malandrino M, Giacomino A, Grosa MM, Lollobrigida F, Martini S, et al. Spatial distribution and potential sources of trace elements in PM10 monitored in urban and rural sites of Piedmont Region. Chemosphere. 2016;145:495-507.
1. Marcazzan GM, Vaccaro S, Valli G, Vecchi R. Characterisation
of PM10 and PM2.5 particulate matter in the ambient air of Milan (Italy). Atmospheric Environment. 2001;35(27):4639-50.