Tehran University of Medical Sciences Journal of Air Pollution and Health 2476-3071 9 3 2024 09 29 403 414 Ali Momen Department of Occupational Health, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Arezo Rezaei Environmental Science and Technology Research Center, Department of Environmental Health Engineering, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Roohollah Rostami Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran. 2024 07 03 2024 08 28 BTEX is a group of hazardous chemical compounds that include benzene, toluene, ethylbenzene, and xylene. The indoor concentration of BTEX is mostly influenced by tobacco smoking, the region within the house, and seasonal variations. This study included three databases: "Google Scholar", "Science Direct", and "Springer". Out of the 1351 articles obtained from the keyword search, only 13 were eventually selected for this study. The most abundant compound found in houses among BTEX was toluene, with a concentration of 13.80±16.50 µg/m3. The results indicated that the concentration of benzene in houses where smoking occurred was greater than in houses where no smoking occurred (7.17±9.42 vs. 2.65±3.77 µg/m3, unpaired Wilcoxon test: p>0.05). The concentration of BTEX in houses was substantially lower than that in cafes (21.10±31.10 vs. 15,100±9740 µg/m3, unpaired Wilcoxon test: p<0.05). The urban region had the most significant accumulation of all BTEX chemicals, with the industrial and rural sectors following suit. The findings indicated that the average levels of BTEX in warm months (such as spring and summer) were higher than in cold months (such as fall and winter) within houses (28.50±44.30 vs. 8.60±7.77 µg/m3, unpaired Wilcoxon test: p > 0.05). The findings indicated that the cancer risk (CR) associated with houses (3.11×10-6) and cafes (3.54×10-3) exceeded the permissible threshold. Moreover, the waterpipe cafes that utilized fruit-flavored tobacco had the greatest CR (4.98×10-3). Furthermore, the presence of smoking, regional factors, and seasonal variations did not result in an increase in the hazard quotient (HQ) in houses beyond the acceptable thresholds. https://japh.tums.ac.ir/index.php/japh/article/view/763 https://japh.tums.ac.ir/index.php/japh/article/download/763/411