Tehran University of Medical Sciences Journal of Air Pollution and Health 2476-3071 9 4 2025 01 30 551 566 Sedighe Afrasiabi Health Engineering, Faculty of Health, Hamadan University of Medical Sciences, Hamadan, Iran. Marzieh Fattahi Darghlou Epidemiology, Faculty of Health, Hamadan University of Medical Sciences, Hamadan, Iran. Younes Mohammadi Department of Epidemiology, Faculty of Health and Health Sciences Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. Mostafa Leili Department of Environmental Health Engineering, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran 2023 12 23 2025 01 08 Today, because of the increasing level of people's need to improve wellbeing in social and individual life, air pollutants have been released that have Pollution harms both human health and the environment. This research examined Benzene, Toluene, Ethylbenzene, and Xylenes (BTEX) levels in indoor air across different global locations from 1963 to 2023. The investigation employed both; a systematic review and meta-analysis method. The health risks associated with long and short-terms exposure to benzene, toluene, ethylbenzene, and xylene were assessed. That average concentration benzene was 23.07 μg⁄m3, toluene was 131.60, ethylbenzene was 28.91, and xylene was 63.87. Also, the health risk assessment based on a 95% confidence level showed that the pollutants in question play a role in causing diseases such as lung neoplasm, stomach neoplasm, colon neoplasm, liver neoplasm, headache, dizziness, nausea, insomnia, etc. Consequently, it is crucial to implement stringent measures aimed at lowering the levels of these contaminants in indoor spaces. https://japh.tums.ac.ir/index.php/japh/article/view/638 https://japh.tums.ac.ir/index.php/japh/article/download/638/420