Tehran University of Medical Sciences Journal of Air Pollution and Health 2476-3071 1 1 2015 11 13 15 20 EN Fatemeh Nemati MSc, Dept. of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Amirhossein Mahvi Assistant Prof. Dept. of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Seyed Mohsen Mohseni MSc, Dept. of Environmental Health Engineering, School of Public Health, Qom University of Medical Sciences, Qom, Iran. 2015 11 10 2015 11 10 Introduction: Nitrogen dioxide (NO2) is a by-product of high-temperature fossil fuel combustion. There is a strong correlation between elevated NO2 concentration and increased mortality and morbidity. Air-Q 2.2.3 model developed by WHO was used for the first time in the present study to evaluate the human communities’ health risk as a result of NO2 exposure in Mashhad, in 2012. Materials and methods: Air-Q 2.2.3 developed by WHO was used for the first time in this study to calculate the risk on human communities as a result of NO2 exposure in Mashhad during 2012. Results: The concentration-response coefficient was 1.14% (95% CI 0.62–1.67%) per 10 μg/m3 increase in NO2 concentration. The study also showed that nearly 3.2% of total cardiovascular deaths, heart attacks, and hospital admissions for chronic obstructive pulmonary were related to NO2 exposure to concentrations beyond 30 μg/m3. Conclusions: The results showed that there is significant correlation between human mortality and air. This assessment estimates the public-health impacts of current patterns of air pollution. Although individual health risks of air pollution are relatively small the public-health consequences are considerable.. Our results, which have also been used for economic valuation, should guide decisions on the assessment of environmental health-policy options. https://japh.tums.ac.ir/index.php/japh/article/view/5 https://japh.tums.ac.ir/index.php/japh/article/download/5/19