Tehran University of Medical Sciences Journal of Air Pollution and Health 2476-3071 8 1 2023 03 29 87 102 Yuvaraj Ramachandran Muthulakshmi Assistant Professor, Department of Geography, University of Madras, Chennai, Tamil Nadu, India Sakthivel Mathivanan Professor, Department of Geography, University of Madras, Chennai, Tamil Nadu, India Marangattu Raghavan Sindhumol Associate Professor, Department of Geography, University of Madras, Chennai, Tamil Nadu, India 2022 12 05 2023 02 25 Introduction: Rapid urbanization and industrial growth are the primary causes of deteriorating urban air quality in developing countries, including India. Vehicular emission is a significant cause of the degradation of air quality. It includes Air Pollution like carbon monoxide, hydrocarbons, oxides of nitrogen, oxides of sulfur, Suspended Particulate Matter (SPM), respiratory Particulate Matters (PM2.5 and PM10), and lead. Materials and methods: The study has considered land use,land cover, land surface temperature, vegetation, literacy rate, vehicle population, population density, and households, finding the responsible causes of air pollutionfor the analysis. Supervised classification using ArcGIS for extracting land use and land cover, Least Slack Time (LST) algorithms have used to extract land surface temperature, spatial interpolation methods like Inverse Distance Weighting (IDW) using ArcGIS for identifying the spatial distribution of Literacy rate, vehicle population, population density and households and finally the multivariate statistical model applied to identify the major responsible factor for air pollution using SPSS. Results: The study reveals that the particulate matter is below the standard value prescribed by the central pollution control board. The Highest air pollution is primarily responsible for vehicle population and industries. Wednesday and Thursday are the maximum pollution in Chennai, whereas it was recorded as very low on Sunday as compared to other days. Conclusion: Regression shows that the vehicle population is responsible for air pollution, followed by the population. https://japh.tums.ac.ir/index.php/japh/article/view/486 https://japh.tums.ac.ir/index.php/japh/article/download/486/341