Tehran University of Medical Sciences Journal of Air Pollution and Health 2476-3071 2 4 2018 04 29 205 210 EN Arman Hashemi Student Research Committee, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran Afshin Shirkani Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran Mohammad Hashemi Student Research Committee, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran Mohammad Davood Salimi Student Research Committee, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran Shayan Behzadi Student Research Committee, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran Alireza Fakharian Student Research Committee, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran Shokrollah Farrokhi Department of Immunology, Asthma and Allergy, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran 2018 01 15 2018 03 17 Air pollution is one of the prevalent causes of respiratory disorders. The main air pollutants are NOx, SOx and O3 that affect quality of life and health. Therefore, assessment of air pollutants effects on the pathogenesis of asthma and allergic diseases may lead to reach a better quality and reduce the prevalence of the diseases. The sample size of this study was according to the index articles containing the terms” Air pollution, Asthma and Allergy”. For writing of this review, 55 articles were studied. Air pollutants induced nonspecific immune and allergic inflammation with enhancing the production of IL - 4, IL - 5, and IL - 13 by Th2 lymphocytes. Our present research demonstrates that, there is significant relationship between air pollution and asthma and allergic diseases. Therefore, air pollution plays role in the pathogenesis and exacerbation of the allergic diseases. https://japh.tums.ac.ir/index.php/japh/article/view/116 https://japh.tums.ac.ir/index.php/japh/article/download/116/65